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"If one is using rimonabant, patients should be monitored carefully for the emergence of depressive symptoms and/or suicidal thoughts," he added. Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study. Those trials compared taking rimonabant (20 milligrams a day) against a placebo. A CB1 antagonist called rimonabant is currently marketed overseas for weight loss. Rimonabant is not yet approved for use in the United States, where it is known as Zimulti.

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